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ABSTRACT
The diagnosis, management and prevention of pertussis
Pertussis (whooping cough) is an acute bacterial disease of the upper respiratory tract that affects children, adolescents and adults all over the world. Given the high infectivity and transmissibility of pertussis-causing bacteria as well as the fact that the most severe complications of pertussis present a substantial risk to young infants, a strategy has been developed to combat pertussis based on active prevention methods to be implemented early in life. It is known, however, that neither vaccination – even though it helped to significantly reduce the death rate due to pertussis, nor a natural infection with Bordetella pertussis does protect against reinfection. In adults with coexisting chronic respiratory and cardiovascular diseases, pertussis may lead to a severe or even life-threatening exacerbation of symptoms of the underlying disease. The diagnosis of pertussis in adults and the initiation of antibiotic therapy are usually delayed, which has both clinical and epidemiological consequences (continued transmission of pertussis-causing pathogens in the patient’s environment). The paper describes the epidemiology, pathomechanism and principles of the diagnosis, treatment and prevention of pertussis.
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