ŚWIĄTECZNA DARMOWA DOSTAWA od 20 grudnia do 8 stycznia! Zamówienia złożone w tym okresie wyślemy od 2 stycznia 2025. Sprawdź >
Podsumowanie
Ciąża u kobiety z padaczką jest ciążą wysokiego ryzyka ze względu na powikłania i zagrożenia, jakie niesie dla matki, a także z uwagi na większe ryzyko wad wrodzonych i nieprawidłowości rozwoju płodu. Przypomnienie i uświadomienie sobie zagrożeń przez neurologów ma na celu poprawę opieki nad ciężarnymi. Od lekarza zależy, jakie leki przepisze kobietom w wieku rozrodczym, jak będzie monitorował leczenie w ciąży i na ile pomoże w wyborze ośrodka położniczego i rodzaju porodu. Ogromne znaczenie ma także edukacja kobiet i włączenie ich w proces leczenia i decydowania o sobie. Konieczne są: wczesna suplementacja kwasem foliowym w prewencji wad cewy nerwowej, monitorowanie poziomu LPP we krwi matki, suplementacja witaminą K pod koniec ciąży w ramach zapobiegania krwotokom u noworodka. Analizy Europejskiego Rejestru Ciąż (EURAP) potwierdzają, że większość kobiet z padaczką wolnych od napadów na początku ciąży ma szansę na utrzymanie takiego stanu.
Abstract
Epilepsy is one of the most common chronic diseases affecting women of reproductive age. Pregnancy is undoubtedly a health problem for women with epilepsy and should be categorized as a high risk pregnancy. At the same time, it is a social problem associated with the high teratogenic potential of antiepileptic drugs and, therefore, requires special education programmes to reduce the risk of such complications. This paper discusses the problems of fertility, probable risks associated with pregnancy for women with epilepsy and the potential developmental risk for the baby, arising from both the disease itself and the therapy. Although most women with epilepsy have uncomplicated pregnancies, they are the group with the highest risk of sudden death among all pregnant women.
Piśmiennictwo
1. Edey S, Moran N, Nashef L. SUDEP and epilepsy-related mortality in pregnancy. Epilepsia 2014;55:72-74.
2. Cantwell R, Clutton-Brock T, Cooper G, et al. Saving mothers’ lives: reviewing maternal deaths to make motherhood safer: 2006-2008. The eighth report of the confidential enquiries into maternal deaths in the United Kingdom. BJOG 2011;118 (suppl 1):1-203.
3. Harden CL, Hopp J, Ting TY, et al. Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidence-based review): obstetrical complications and change in seizure frequency: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009;73:126-32.
4. Viale L, Allotey J, Cheong-See F, et al. EBM CONNECT Collaboration Epilepsy in pregnancy and reproductive outcomes: a systematic review and meta-analysis. Lancet 2015; doi: 10.1016/S0140-6736(15)00045-8.
5. Patsalos PN, Froscher W, Pisani F, et al. The importance of drug interactions in epilepsy therapy. Epilepsia 2002;43:365-85.
6. Gaffield M, Culwella KR, Leeb R. The use of hormonal contraception among women taking anticonvulsant therapy. Contraception 2011;83:16-29.
7. Crawford P, Chadwick DJ, Martin C, et al. The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids. Br J Clin Pharmacol 1990;30:892-6.
8. Fattore C, Cipolla G, Gatti G, et al. Induction of ethinylestradiol and levonorgestrel metabolism by oxcarbazepine in healthy women. Epilepsia 1999;40:783-7.
9. Herzog AG, Blum AS, Farina EL, et al. Valproate and lamotrigine level variation with menstrual cycle phase and oral contraceptive use. Neurology 2009;72:911-4.
10. Ohman I, Luef G, Tomson T. Effects of pregnancy and contraception on lamotrigine disposition: new insights through analysis of lamotrigine metabolites. Seizure 2008;17:199-202.
11. Aurlien D, Larsen JP, Gjerstad L, et al. Increased risk of sudden unexpected death in epilepsy in females using lamotrigine: a nested, case-control study. Epilepsia 2012;53(2):258-66.
12. Hesdorffer DC, Tomson T. Sudden unexpected death in epilepsy. Potential role of antiepileptic drugs. CNS Drugs 2013;27(2):113-9.
13. Harden CL. Polycystic Ovaries and Polycystic Ovary Syndrome in Epilepsy: Evidence for Neurogonadal Disease. Epilepsy Curr 2005;5(4):142-6.
14. Verrotti A, D’Egidio C, Mohn A, et al. Antiepileptic drugs, sex hormones, and PCOS. Epilepsia 2011;52(2):199-211.
15. Bauer J, Jarre A, Klingmüller D, et al. Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women. Epilepsy Res 2000;41(2):163-7.
16. Hu X, Wang J, Dong W, et al. A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy. Epilepsy Res 2011;97(1-2):73-82.
17. Svalheim S, Taubøll E, Luef G, et al. Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults. Epilepsy Behav 2009;16(2):281-7.
18. Lassi ZS, Salam RA, Haider BA, et al. Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes. Cochrane Database Syst Rev 2013 Mar 28;3:CD006896.
19. Fekete K, Berti C, Trovato M, et al. Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutr J 2012;19:11-75.
20. Skórka A, Gieruszczak-Białek D, Pieścik M, et al. Effects of prenatal and/or postnatal (maternal and/or child) folic acid supplementation on the mental performance of children. Crit Rev Food Sci Nutr 2012;52(11):959-64.
21. Wilson RD, Audibert F, Brock JA, et al. Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies. J Obstet Gynaecol Can 2015;37(6):534-52.
22. Asadi-Pooya AA. High dose folic acid supplementation in women with epilepsy: are we sure it is safe? Seizure 2015;27:51-3.
23. Valera-Gran D, García de la Hera M, Navarrete-Muñoz EM, et al. Infancia y Medio Ambiente (INMA) Project. Folic acid supplements during pregnancy and child psychomotor development after the first year of life. JAMA Pediatr 2014;168(11):e142611.
24. Ban L, Fleming KM, Doyle P, et al. Congenital Anomalies in Children of Mothers Taking Antiepileptic Drugs with and without Periconceptional High Dose Folic Acid Use: A Population-Based Cohort Study. PLoS One 2015;6;10(7):e0131130.
25. Shere M, Bapat P, Nickel C, et al. Association Between Use of Oral Contraceptives and Folate Status: A Systematic Review and Meta-Analysis. J Obstet Gynaecol Can 2015;37(5):430-8.
26. Bukowski R, Malone FD, Porter FT, et al. Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study. PLoS Med 2009;6(5):e1000061.
27. Tomson T, Battino D, Bonizzoni E, et al. EURAP Study Group. Antiepileptic drugs and intrauterine death: A prospective observational study from EURAP. Neurology 2015;85(7):580-8.
28. Tomson T, Battino D, Bonizzoni E, et al. EURAP study group. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011;10(7):609-17.
29. Tomson T, Battino D, Bonizzoni E, et al. EURAP Study Group. Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study. Neurology 2015;85(10):866-72.
30. Veiby G, Daltveit AK, Engelsen BA, et al. Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J Neurol 2014;261(3):579-88.
31. Bromley R, Weston J, Adab N, et al. Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. Cochrane Database Syst Rev 2014 Oct 30;10:CD010236.
32. EURAP Study Group. Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. Neurology 2006;66(3): 354-60.
33. Vajda FJE, O’Brien TJ, Lander CM, et al. Does pregnancy per se make epilepsy worse? Acta Neurol Scand 2015, DOI: 10.1111/ane.12479
34. Rozporządzenie Ministra Zdrowia z dnia 20 września 2012 r. w sprawie standardów postępowania medycznego przy udzielaniu świadczeń zdrowotnych z zakresu opieki okołoporodowej sprawowanej nad kobietą w okresie fizjologicznej ciąży, fizjologicznego porodu, połogu oraz opieki nad noworodkiem. http://www.mz.gov.pl/zdrowie-i-profilaktyka/zdrowie-matki-i-dziecka/standard-opieki-okoloporodowej
35. Harden CL, Pennell PB, et al. American Academy of Neurology; American Epilepsy Society: Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidence based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009;73(2):142-9; w wersji pol. Praktyczne wytyczne: uaktualnienie dotyczące leczenia kobiet chorych na padaczkę – postępowanie w ciąży (przegląd wiarygodnych i aktualnych danych naukowych): witamina K, kwas foliowy, stężenie leków we krwi i karmienie piersią. Neurology 2009;6(38):23-32.
36. Harden CL, Hopp J, Ting TY, et al. Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidence-based review): obstetrical complications and change in seizure frequency: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009;73:126-32.
37. Harden CL, Meador KJ, et al. American Academy of Neurology; American Epilepsy Society: Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidence based review): teratogenesis and perinatal outcomes: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009;73(2):133-41.
38. Veiby G, Bjørk M, Engelsen BA, et al. Epilepsy and recommendations for breastfeeding. Seizure 2015;28:57-65.