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ABSTRACT
Expert group statement on the use of special medical nutrition in the treatment of functional gastrointestinal disorders
Functional gastrointestinal disorders (FGIDs), such as infant regurgitation, infant colic or functional constipation, are among the most common reasons for consultations with pediatricians and pediatric gastroenterologists. According to available data, more than half of infants are affected. Current diagnostic criteria for FGIDs are based on the Rome IV criteria. The occurrence of FGIDs in infancy may be related to immaturity of the gastrointestinal tract and the varying time patterns of functional gastrointestinal maturation. FGIDs are usually temporary and seem to have no long-term consequences; however, recent studies have shown that the presence of FGIDs in infancy may increase the risk of functional disorders in later life.
FGIDs are associated with considerable anxiety and stress on the part of the parents, often reducing the quality of life of the entire family. The most recommended, effective and safe method of management of FGIDs is nutritional intervention, as opposed to often invasive diagnostic procedures and pharmacotherapy, whose effectiveness is sometimes not well documented and which are not neutral to the child’s health. Dietary modifications used in food for special medical purposes (FSMP) for infants with FGIDs include the addition of probiotics and/or oligosaccharides, hydrolysis of cow's milk protein, or reduction of lactose content, addition of beta-palmitate or thickeners. It is advisable and recommended that FGIDs should be introduced before drug treatment, but always under medical supervision. This article presents current nutritional recommendations for the treatment of functional gastrointestinal disorders in infants.
Piśmiennictwo
1. Benninga MA, Nurko S, Faure C, et al. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology 2016;150:1443-55
2. Vandenplas Y, Abkari A, Bellaïche M, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015;61(5):531-7
3. Bellaïche M, Oozeer R, Gerardi-Temporel G, et al. Multiple functional gastrointestinal disorders are frequent in formula-fed infants and decrease their quality of life. Acta Paediatr 2018;107(7):1276-82
4. Vik T, Grote V, Escribano J, et al. Infantile colic, prolonged crying and maternal postnatal depression. Acta Paediatr 2009;98:1344-8
5. Howard CR, Lanphear N, Lanphear BP, et al. Parental responses to infant crying and colic: the effect on breastfeeding duration. Breastfeed Med 2006;1:146-55
6. Akman I, Kusçu K, Ozdemir N, et al. Mothers’ postpartum psychological adjustment and infantile colic. Arch Dis Child 2006;91:417-9
7. Keefe MR, Kotzer AM, Froese-Fretz A, et al. A longitudinal comparison of irritable and nonirritable infants. Nurs Res 1996;45:4-9
8. van den Boom DC, Hoeksma JB. The effect of infant irritability on mother–infant interaction: a growth-curve analysis. Developmental Psychology 1994;30:581-90
9. Räihä H, Lehtonen L, Huhtala V, et al. Excessively crying infant in the family: mother-infant, father-infant and mother-father interaction. Child Care Health Dev 2002;28:419-29
10. Indrio F, Di Mauro A, Riezzo G, et al. Infantile colic, regurgitation, and constipation: an early traumatic insult in the development of functional gastrointestinal disorders in children? Eur J Pediatr 2015;174:841-2
11. Brown M, Heine RG, Jordan B. Health and well-being in school-age children following persistent crying in infancy. J Paediatr Child Health 2009;45:254-62
12. Rautava P, Lehtonen L, Helenius H, et al. Infantile colic: child and family three years later. Pediatrics 1995;96:43-7
13. Salvatore S, Abkari A, Cai W, et al. Review shows that parental reassurance and nutritional advice help to optimize the management of functional gastrointestinal disorders in infants. Acta Paediatr 2018;107(9):1512-20
14. Mahon J, Lifschitz C, Ludwig T, et al. The costs of functional gastrointestinal disorders and related signs and symptoms in infants: a systematic literature review and cost calculation for England. BMJ Open 2017;7:e015594
15. IFFGD Publication #845 by Paul E. Hyman, MD, Louisiana State University and Children’s Hospital New Orleans, LA and Susan R. Orenstein, MD, University of Pittsburgh, PA
16. Stagnara J, Blanc JP, Danjou G, et al. Clinical data on the diagnosis of colic in infants. Survey in 2,773 infants aged 15-119 days. Groupment des pédiatres de la région de Lyon (GPRL), le Groupment lyonnais de recherche en pédiatrie ambulatoire (GLYRPA), l'association des pédiatres de la région stéphanoise (APRS) et la Formation pédiatrique grenobloise (FPG). Arch Pediatr 1997;4(10):959-66
17. Infante Pina D, Badia Llach X, Ariño-Armengol B, et al. Prevalence and dietetic management of mild gastrointestinal disorders in milk-fed infants. World J Gastroenterol 2008;14(2):248-54
18. Pärtty A, Kalliomäki M, Salminen S, et al. Infant distress and development of functional gastrointestinal disorders in childhood: is there a connection? JAMA Pediatr 2013;167: 977-8
19. Indrio F, Di Mauro A, Riezzo G, et al. Infantile colic, regurgitation, and constipation: an early traumatic insult in the development of functional gastrointestinal disorders in children? Eur J Pediatr 2015;174(6):841-2
20. Ludwik Th. The approaches to common gastrointestinal symptoms in infancy. Danone Nutricia Research Symposium 2014
21. Pijpers M, Bongers MEJ, Benninga MA, et al. Functional constipation in children: a systematic review on prognosis and predictive factors. J Pediatr Gastroenterol Nutr 2010;50: 256-68
22. Tamburini S, Shen N, Wu HC, et al. The microbiome in early life: implications for health outcomes. Nat Med 2016;22(7):713-22
23. Whitehead WE, Palsson OS, Feld AD, et al. Utility of red flag symptom exclusions in the diagnosis of irritable bowel syndrome. Aliment Pharmacol Ther 2006;24(1):137-46
24. Vandenplas Y, Alturaiki MA, Al-Qabandi W, et al. Middle East consensus statement on the diagnosis and management of functional gastrointestinal disorders in <12 months old infants. Pediatr Gastroenterol Hepatol Nutr 2016;19(3):153-61
25. Vandenplas Y, Benninga M, Broekaert I, et al. Functional gastro-intestinal disorder algorithms focus on early recognition, parental reassurance and nutritional strategies. Acta Paediatr 2016;105(3):244-52
26. Scarpato E, Quitadamo P, Roman E, et al. Functional gastrointestinal disorders in children: a survey on clinical approach in the Mediterranean area. J Pediatr Gastroenterol Nutr 2017;64:e142-6
27. Glanville J, Ludwig T, Lifschitz C, et al. Costs associated with functional gastrointestinal disorders and related signs and symptoms in infants: a systematic review protocol. BMJ Open 2016;6(8):e011475
28. Vandenplas Y, Alarcon P, Alliet P, et al. Algorithms for managing infant constipation, colic, regurgitation and cow's milk allergy in formula-fed infants. Acta Paediatr 2015;104(5): 449-57
29. Bode L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology 2012;22:1147-62
30. Hegar B, Wibowo Y, Basrowi RW, et al. The role of two human milk oligosaccharides, 2'-fucosyllactose and lacto-N-neotetraose, in infant nutrition Pediatr. Gastroenterol Hepatol Nutr 2019;22(4):330-40
31. Beghin L, Tims S, Roelofs M, et al. Combination of the role of two human milk oligosaccharides, 2'-fucosyllactose and Lacto-N-Neotetraose, in infant nutrition prebiotic oligosaccharides and fermented infant formula (with Bifidobacterium breve C50 and Streptococcus thermophilus O65) is safe and modulates the gut microbiota towards a microbiota closer of that of breastfed infants. J Pediatr Gastroenterol Nutr 2019;68:p1-1243. N-O-039
32. Moro G, Minoli I, Mosca M, et al. Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants. J Pediatr Gastroeneterol Nutr 2002;34(3):291-5
33. Moro G, Arslanoglu S, Stahl B, et al. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child 2006;91(10):814-9
34. Bezirtzoglou E, Tsiotsias A, Welling GW. Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH). Anaerobe 2011;17: 478-82
35. Sela DA, Mills DA. Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides. Trends Microbiol 2010;18:298-307
36. Savino F, Maccario S, Castagno E, et al. Advances in the management of digestive problems during the first months of life. Acta Pædiatrica 2005;94(Suppl 449):120-4
37. Gutiérrez-Castrellón P, Indrio F, Bolio-Galvis A, et al. Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: systematic review with network meta-analysis. Medicine (Baltimore) 2017;96(51):e9375
38. Litmanovitz I, Bar-Yoseph F, Lifshitz Y, et al. Reduced crying in term infants fed high beta-palmitate formula: a double-blind randomized clinical trial. BMC Pediatr 2014;14:152
39. Vandenplas Y, Hachimi-Idrissi S, Casteels A, et al. A clinical trial with an “anti-regurgitation” formula. Eur J Pediatr 1994;6:419-23
40. Chao HC, Vandenplas Y. Comparison of the effect of a cornstarch thickened formula and strengthened regular formula on regurgitation, gastric emptying and weight gain in infantile regurgitation. Dis Esophagus 2007;20(2):155-60
41. Lasekan JB, Linke HK, Oliver JS, et al. Milk protein-based infant formula containing rice starch and low lactose reduces common regurgitation in healthy term infants: a randomized, blinded, and prospective trial. J Am Coll Nutr 2014;33(2):136-46
42. Horvath A, Dziechciarz P, Szajewska H. The effect of thickened-feed interventions on gastroesophageal reflux in infants: systematic review and meta-analysis of randomized, controlled trials. Pediatrics 2008;122(6):e1268-77
43. Sung V, D'Amico F, Cabana MD, et al. Lactobacillus reuteri to treat infant colic: a meta-analysis. Pediatrics 2018;141(1):e20171811
44. Pärtty A, Luoto R, Kalliomäki M, et al. Effects of early prebiotic and probiotic supplementation on development of gut microbiota and fussing and crying in preterm infants: a randomized, double-blind, placebo-controlled trial. J Pediatr 2013;163(5):1272-7
45. Rodriguez-Herrera A, Mulder K, Bouritius H, et al. Gastrointestinal tolerance, growth and safety of a partly fermented formula with specific prebiotics in healthy infants: a double-blind, randomized controlled trial. Nutrients 2019;5(11):1530
46. Vandenplas Y, Ludwig T, Bouritius H, et al. Randomized controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic. Acta Paediatr 2017;106(7):1150-8
47. Cohen S, Bueno de Mesquita M, Mimouni FB. Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review. Br J Clin Pharmacol 2015;80:200-8
48. Bentley D, Lawson M, Lifschitz CH. Pediatric gastroenterology and clinical nutrition. London: Remedica, 2002:215
49. Salvatore S, Savino F, Singendonk M, et al. Thickened infant formula: what to know. Nutrition 2018;49:51-6
50. Vandenplas Y, Rudolph CD, Di Lorenzo C, et al. North American Society for Pediatric Gastroenterology Hepatology and Nutrition, European Society for Pediatric Gastroenterology Hepatology and Nutrition. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr 2009;49(4): 498-547
51. Gonzalez Ayerbe JI, Hauser B, Salvatore S, et al. Diagnosis and management of gastroesophageal reflux disease in infants and children: from guidelines to clinical practice. Pediatr Gastroenterol Hepatol Nutr 2019;22(2):107-21
52. Gordon M, Biagioli E, Sorrenti M, et al. Dietary modifications for infantile colic. Cochrane Database Syst Rev 2018;10(10):CD011029
53. Harb T, Matsuyama M, David M, et al. Infant colic – what works: a systematic review of interventions for breast-fed infants. J Pediatr Gastroenterol Nutr 2016;62(5):668-86
54. Sung V, D’Amico F, Cabana MD, et al. Lactobacillus reuteri to treat infant colic: a meta-analysis. Pediatrics 2018;141:pii:e20171811
55. Baldassarre ME, Di Mauro A, Tafuri S, et al. Effectiveness and safety of a probiotic-mixture for the treatment of infantile colic: a double-blind, randomized, placebo-controlled clinical trial with fecal real-time PCR and NMR-based metabolomics analysis. Nutrients 2018;10(2):195
56. Savino F, Palumeri E, Castagno E, et al. Reduction of crying episodes owing to infantile colic: a randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr 2006;60:1304-10
57. Skórka A, Pieścik-Lech M, Kołodziej M, et al. To add or not to add probiotics to infant formulae? An updated systematic review. Benef Microbes 2017;8(5):717-25
58. Skórka A, Pieścik-Lech M, Kołodziej M, et al. Infant formulae supplemented with prebiotics: Are they better than unsupplemented formulae? An updated systematic review. Br J Nutr 2018;119(7):810-25