ABSTRACT

Diagnosis of splenomegaly and hypersplenism

The spleen is an organ that performs numerous functions, including immune and hematopoietic functions.

Splenomegaly may be caused by a process that increases normal splenic function (e.g., hemolysis) or may be due to infiltrative, infectious, inflammatory or vascular disorders.

Enlargement of the spleen may cause hypersplenism, which is sequestration and excessive destruction of blood cells by splenic macrophages. Hypersplenism refers to symptoms that include splenomegaly and peripheral cytopenia and can be caused by many diseases, which, in turn, affects the prognosis of hypersplenism.

Piśmiennictwo

1. Gołąb J, Jakóbisiak M, Lasek W. Immunologia. Warszawa: Wydawnictwo Naukowe PWN, 2004

2. Adamowicz-Salach A, Fabijańska-Mitek J. Niedokrwistości autoimmunohemolityczne. W: Socha J (red.). Choroby autoimmunologiczne u dzieci. Warszawa: Wydawnictwo Lekarskie PZWL, 2005

3. Chybicka A, Sawicz-Birkowska K, Kazanowska B. Onkologia i hematologia dziecięca. Warszawa: Wydawnictwo Lekarskie PZWL, 2021

4. Rosenberg HK, Markowitz RI, Kolberg H, et al. Normal splenic size in infants and children: sonographic measurements. AJR Am J Roentgenol 1991;157(1):119-21

5. Gielchinsky Y, Elstein D, Hadas-Halpern I, et al. Is there a correlation between degree of splenomegaly, symptoms and hypersplenism? A study of 218 patients with Gaucher disease. Br J Haematol 1999;106(3):812-6

6. Lv Y, Lau WY, Li Y, et al. Hypersplenism: history and current status. Exp Ther Med 2016;12(4):2377-82

7. Boyer TD, Habib S. Big spleens and hypersplenism: fix it or forget it? Liver Int 2015;35(5):1492-8

Do góry